Methyl Protect | Vitamin B6, B12, Folate Drops | Biogenesis Nutraceuticals | 2 oz
What is Methyl Protect? Methyl Protect by Biogenesis Nutraceuticals is a highly absorbable liquid form of provides therapeutic doses of vitamins B6, B12, and folate (folic acid). Proper endogenous methylation activity as well as healthy production of red blood cells, neurotransmitters, hormones, and nucleic acids are supported by these essential B vitamins. The compound homocysteine occurs as a byproduct of the series of B12/B6/folate-dependent methylation reactions involved in methionine/cysteine metabolism. In clinical trials, supplementation with the involved B vitamins has been shown to reduce circulating homocysteine levels and consequently, support cardiovascular health. Elevated levels of homocysteine have been associated with cardiovascular risk through believed promotion of atherosclerotic plaque development and enhanced blood clotting activity.
Vitamin B6 (Pryridoxal 5’-Phosphate) is required for the synthesis of the neurotransmitters serotonin and norepinephrine and for myelin formation. Vitamin B6 is a water-soluble vitamin that participates in over 100 body reactions. The phosphate ester derivative pyridoxal 5’-phosphate (PLP) is the principle coenzyme form and is a cofactor for endogenous transaminase activity. PLP-dependent reactions include the synthesis of both serotonin and the catecholamines and the production of hemoglobin, steroid hormones, and nucleic acids. Vitamin B6 deficiency has been linked to emotional abnormalities, carpal tunnel, low immunity, and premenstrual syndrome. Pyridoxine deficiency in adults principally affects the peripheral nerves, skin, mucous membranes, and the blood cell system. Conversion of homocysteine to the amino acid cysteine requires two PLP-dependent reactions. This pathway facilitates the de novo synthesis of cysteine from methionine and also provides an alternative pathway for the breakdown of homocysteine. Pyridoxine is frequently used in combination with other B vitamins in vitamin B complex formulations.
Vitamin B12 (Methylcobalamin) is a coenzyme involved in nucleic acid metabolism, red blood cell synthesis, methyl transfer, and myelin synthesis and repair. Without adequate blood levels of B12, you can experience symptoms related to low energy, mental fatigue, mood changes, sleep difficulties, and even occasional indigestion. Absorption of vitamin B12 is dependent upon gastric secretion of the glycoprotein intrinsic factor. Among aging adults, secretion of intrinsic factor is often reduced, leading to an increased risk of vitamin B12 deficiency and the related pernicious anemia. The liquid form of B12 in Methyl Protect allows people to bypass the intrinsic factor-dependent pathway for enhanced absorption. Vitamin B12 deficiency is also common among strict vegans and those who have undergone long-term treatment with certain antibiotics. Vitamin B12 depletion and deficiency are much more common than previously thought, especially in the over-60 population. In fact, it’s believed that almost one in four people over 60 have deficient levels. Long-term insufficient intake of vitamin B12 can lead to megaloblastic anemia, impaired folate metabolism, and many neurological disorders including depression, paresthesias, and memory loss. Remethylation of homocysteine to methionine also requires the methylcobalamin form of B12.
Folate (Folic Acid) is the 5-formyl derivative of tetrahydrofolate (THF) and is found naturally in foods. Folate, or vitamin B9, has multiple functions in the body, including DNA replication, nucleotide biosynthesis, and amino acid metabolism. The human body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in biological reactions involving folate. It participates in body reactions as one of the five forms of THF and serves as an acceptor and donor of one carbon units and methyl groups. Insufficient intake of folate has been linked to numerous adverse health effects, including increased risk of dementia, cancer, and birth defects. The association between folate deficiency and neural tube defects is so evident that the U.S. Low levels of folate can also lead to homocysteine accumulation. Folate as N5-methyl THF functions as a methyl donor to vitamin B12 in the methionine synthase reaction that regenerates methionine from homocysteine. Without sufficient folate, regeneration of methionine cannot occur, resulting in possible homocystenemia. This reaction is also dependent upon B12 availability as it serves as the prosthetic group for methyl donation within the reaction. Insufficient B12 can also impair the ability of N5-methyl THF to be converted back to THF via methyl donation. As a result, endogenous reactions that are dependent upon THF as a substrate, such as purine synthesis, are impaired. This phenomenon is known as the “methyl-folate trap” and demonstrates the complex interrelationship between folate and vitamin B12. Common symptoms of folate deficiency include diarrhea, macrocytic anemia with weakness or shortness of breath, nerve damage with weakness and limb numbness, pregnancy complications, mental confusion, forgetfulness or other cognitive declines, mental depression, sore or swollen tongue, peptic or mouth ulcers, headaches, heart palpitations, irritability, and behavioral disorders.
Methyl Protect drops by Biogenesis Nutraceuticals Highlights:
- Is an unique convenient liquid formulation of dietary methylation cofactors
- Supplies vitamin B6, B12, and folate.†
- Helps maintain proper neurological function
- Nutritional support for normal erythropoiesis
- Supports optimal homocysteine levels for cardiovascular health
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How Do I use Methyl Protect Drops? Directions: As a dietary supplement, take 1 serving one time per day or as directed by your healthcare professional. Shake before use.
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STORE IN A COOL, DRY PLACE. KEEP OUT OF REACH OF CHILDREN.
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“Methyl Protect drops make it easy for me to get my B vitamins. I feel a definite lift in my energy levels.” Edith Myers
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