Sulforaphane GlucosinolatePro+ Cell Protect SGS | Estrogen Metabolite Eliminator | Protégé Laboratories 30 Caps
Pro+ Cell Protect SGS by Protege Laboratories? sulforaphane glucosinolate “We expect that by 2030 there will be up to 580,000 new cancer cases each year – almost one third more than now,” Nobel Prize-winning doctor and president of German Cancer Aid, Harald zur Hausen. We are continually bombarded by toxic chemicals that are likely playing a role in cancer development. Broccoli could possibly be considered one of the top foods for immune protection.
Pro+ Cell Protect SGS contains a specially cultivated form of broccoli seed. This proprietary and patented variety of broccoli, Brassica oleracea Hopkins, is particularly rich in glucoraphanin (better known as sulforaphane glucosinolate). Sulforaphane glucosinolate is the direct precursor to sulforaphane. Sulforaphane supports the safe transformation and elimination of estrogen metabolites because it can stimulate both enzymes glutathione S-transferase and quinine reductase which convert estrogen quinones into safer metabolites. Studies have shown that estrogen quinones may interfere with purines, thus potentially causing DNA damage, which may be a cancer initiating event.
You would have to consume 500 grams of Fresh Broccoli or 100 grams of sprouts to acquire the same level of sulforaphane that you can get from one capsule of Pro+ Cell Protect SGS!
There are other choices available, but consider the Pro+ Cell Protect SGS benefits not found in any other sulforaphane product:
- all natural, vegetable concentrate
- Supercritical CO2 extraction of broccoli seed – no chemical solvents are used in the extraction
- unmatched stability
- free of maltodextrin coating
Glucosinolate, also known as glucoraphanin, is a sulfur-rich compound found in broccoli. Glucosinolate gets hydrolyzed by an enzyme called myrosinase and quickly converts into sulforaphane. Sulforaphane was isolated and identified in 1992. The myrosinase enzyme is compartmentalized in certain parts of the plant. Chopping and chewing of raw cruciferous vegetables, as well as cooking, brings this enzyme in contact with glucoraphanin. Although cooking can inactivate myrosinase, glucosinolates can still be converted to sulforaphane in the gut by bacterial enzymes making both raw and cooked broccoli beneficial. Sulforaphane is considered a major reason that Cruciferous vegetables are so beneficial to health and capable of preventing many forms of disease. In spite of their well-researched value in human health, they are not popular food choices. Cells are naturally equipped with their own internal Defense System.
How does sulforaphane work? The dietary isothiocynate Sulforaphane targets numerous biological pathways that (1) modulate Phase I enzymes and (2) elevate Phase II enzymes that are present in all cells. Once inside the cells, it sends a signal to individual cellular enzymes that turns on the natural cellular defenses housed in all cells. In some cases, sulforaphane is capable of restoring the gene’s activity towards normal cell progression. Cells are naturally equipped with their own internal defense system. Much of the cell’s ability to defend itself is due to two main factors, focusing on sulforaphane’s ability to produce:
- the antioxidants that quench harmful free radicals
- detoxification enzymes to break down toxins.
Sulforaphane may delay the appearance of Aging and Chronic Disease that is attributed to:
- UV Radiation
- Free Radicals
- Shear Stress.
How does the body deal with toxic chemicals? Unfortunately, we are exposed to chemicals daily, many of which are carcinogenic. One of the body’s first lines of defense against cancer is the detoxification system which is designed to process and rid these chemicals mainly through the liver. The liver acts similar to a dishwasher that first cleans the dishes and then rinses them with hot water. The liver also puts chemicals through two steps of detoxification called Phase I and Phase II.
The goal of detoxification is to convert all toxins into water-soluble form so they can enter the bloodstream and go to the liver for further processing and ultimately be eliminated through the urine or intestines in a safer form than when they entered the body. Phase I cytochrome P450 enzyme activity provides this initial conversion of toxins to more water soluble form through various reactions, including hydroxylation, oxidation, reduction, and others. Phase II is a complicated process that involves a joining of the toxic intermediate produced through the phase I system to another substance which can shuttle it out of the body. This joining process is known as “conjugation”. It involves various enzymes including glutathione S-transferase, and major pathways including glutathione conjugation, glucuronidation, glycination and sulfation.
In the human body, Sulforaphane reacts with Glutathione (GSH) to produce various conjugated metabolites within the cell. These conjugated metabolites are the responsible for controlling the level of oxidative stress, and cellular detoxification. These food-derived metabolites have their most beneficial effects in the digestive tract, neutralizing the free radicals frequently found in our environment and food supply. Quenching free radicals in the digestive tract minimizes the numbers of these harmful substances entering the bloodstream. This is why it is a good idea to consume brightly-colored fruits and vegetables with a meat-containing meal or other foods such as deep fried foods where there is likely to be increased free radical activity
Where does Pro+ Cell Protect SGS come in? Broccoli seed is especially high in sulforaphane glucosinolate and contains much higher levels than broccoli sprouts. The patented broccoli seed found in Pro+ Cell Protect SGS is standardized to 10% sulforaphane glucosinolate. The sulforaphane is able to upregulate phase II enzymes to allow for full and proper detoxification of unsafe chemicals. Over aggressive phase I activation of chemicals in the presence of a slow or sluggish phase II system can result in increased toxic burden from highly reactive free radicals, possible DNA damage, and potentially greater cancer risk.
What makes Pro+ Cell Protect SGS by Protégé Laboratories unique? Pro+ Cell Protect SGS contains a specially cultivated, patented form of broccoli seed. This proprietary and patented variety of broccoli, Brassica Oleracea Hopkins, is naturally rich in glucoraphanin, a glucosinolate that is the direct precursor to sulforaphane. This is grown and processed in North America and the intermediate material is shipped to Germany where they extract 99% of the oil from the seed meal using a very clean and non-toxic process called super critical fluid extraction. Only food grade, GRAS (Generally Recognized as Safe), liquid carbon dioxide is used as the solvent. The process and final product are considered “all natural” and absolutely no solvent residue remains in the finished product.
The patented broccoli seed used in Pro+ Cell Protect SGS is 15-20 times more potent than broccoli sprouts! One would have to consume approximately 1 lb. of broccoli to equal 1 capsule of Pro+ Cell Protect SGS, which contains the latest, more potent 10% concentration of sulforaphane glucosinolate material. This is a second generation material which has double the potency over previous materials offered in the market. The shelf life on this new material has also been vastly extended due to a special extrusion process of the broccoli seed meal which deactivates the myrosinase enzyme. This will ensure the product does not prematurely convert to sulforaphane in the capsule which, will lead to instability and degradation of the material and will greatly decrease the shelf life as well as the effectiveness of the product.
More Pro+ Cell Protect SGS facts:
- Per 1 gram of material (2 capsules) there is only 1.5 mcg of vitamin K (equivalent of 1 potato), which should make this product acceptable for people taking blood thinners like Coumadin.
- Unlike consuming lots of cruciferous veggies, because of the special processing BroccoProtect goes through, it does not contain goitrogens and will not block the uptake of iodine by the thyroid.
- There are currently over 500 journal publications, as well as documented epidemiological evidence, showing that diets rich in broccoli: are chemoprotective and may reduce the risk of many forms of cancer. promote reduction of PSA levels possess anti-inflammatory properties.